Sunday saw a six-match unbeaten run in all competitions come to a comprehensive end as Mourinho and many of the United coaching staff endured a nightmare afternoon at their old stomping ground.

Pedro’s goal after 30 seconds threw the visitors off kilter at Stamford Bridge, with Gary Cahill, Eden Hazard and N’Golo Kante all scoring as the Blues went on to handed out a chastening defeat.

Wednesday will be the second time City boss Pep Guardiola and Mourinho have faced one another since taking up residency in Manchester.

A swashbuckling display - despite a nervy debut for Claudio Bravo - saw City run out 2-1 victors at Old Trafford when the sides met in the Premier League last month, with the upcoming EFL Cup fourth-round encounter at the same venue offering both the chance to get things back on track.

Mourinho expects a reaction from his players, who are now five points behind of the top four in seventh place.

“I would prefer to play (next) in the Premier League. It’s a bad feeling in the Premier League. With the combination of results the gap to the top is six points,” Mourinho said in an interview with MUTV after the Chelsea match and looking ahead to the cup tie.

elastico superfly black “We have had a very difficult period of matches. We lost points this week and, even in the match when we played phenomenal against Stoke, we lost points then. Now we need to win matches.

“I am not saying they are easy ones, but we have Burnley, we have Swansea, West Ham, Sunderland, Middlesbrough - matches that we need to win and the top four, the top five, they have to play between themselves like we did this week against Chelsea and Liverpool.

“They are going to lose points too, so we are in the run, but there is no way to hide because I think our faces speak by themselves.”

16+ PureChaos white Mourinho added: “We are really, really sad, but again this is not for kids, this is for men and…we have to be men and work for the next one.”

Former Chelsea midfielder Juan Mata, who was introduced at half-time against his old club, says the scoreline “hurts”, but knows United can ill-afford to wallow in self-pity.

mercurial superfly cr7 blue “We must carry on. Luckily, in three days we have a very important fixture, and as from now we must focus on this new opportunity to get better,” Mata wrote on his blog.

superfly v red “It sounds like a cliche but it’s true: when we win and everybody praises you it’s easy to be united and celebrate together, but it is now, after such a defeat, when we must remain mentally strong and keep going.

“Together we win and together we lose.”

mercurial vapor v red United defender Eric Bailly suffered what a knee ligament injury when he limped off after 52 minutes, and continues to be assessed, while captain Wayne Rooney missed the Stamford Bridge defeat because of a calf problem.

Mourinho, meanwhile, could discover on Tuesday whether he will face a charge from the Football Association following comments about referee Anthony Taylor prior to the goalless draw at Liverpool.

The FA has contacted the United boss for his observations, which are being reviewed.